{"id":10,"date":"2024-11-13T14:40:23","date_gmt":"2024-11-13T13:40:23","guid":{"rendered":"https:\/\/projects.pmfst.unist.hr\/inabioamp\/?page_id=10"},"modified":"2025-12-23T15:04:19","modified_gmt":"2025-12-23T14:04:19","slug":"inabioamp","status":"publish","type":"page","link":"https:\/\/projects.pmfst.unist.hr\/inabioamp\/","title":{"rendered":"InABioAMP"},"content":{"rendered":"
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\"\"InABioAMP<\/h1>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row visibility=”visible-nb”][vc_column][vc_empty_space][vc_column_text css=”.vc_custom_1734441195432{margin-bottom: 0px !important;}”]\n

<\/h1>\n

InABioAMP\"\"<\/h1>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1733849390613{margin-bottom: 0px !important;}”]\n

HRZZ IP-2022-10-8432 “Investigating the role of association in bioactivity of antimicrobial peptides: from measurements, modeling to design and back”\u00a0<\/span><\/h3>\n

Antimicrobial peptides (AMPs) are critical components of almost all forms of life\u2019s innate defence systems, serving as a first line of defence against invading pathogens in plants and animals. As a result, they are being extensively researched, with a focus on their potential as novel anti-infective drug leads, particularly in the context of emerging drug resistance in bacteria, which is one of the great challenges of our time. Starting with designed or naturally occurring AMPs, the proposed study will advance understanding of the structure-function relationship and identify AMPs with potential for clinical application by combining structural and dynamic properties obtained through molecular dynamics simulation with the biological and biophysical characterization of these peptides in the presence of model membranes and measurements of their activity on real membranes in microbial or host cells. The project also aims to create a new program for designing and characterising AMPs using a neural network approach. The main line of research will be to discover the mode of action related to peptide self-assembly behind the observed activity and toxicity. This work will provide opportunities to strengthen the connection between theoretical and experimental work in Split, put into use some of the new equipment acquired in the recent infrastructure project, and establish further cooperation with international laboratories. The project will also advance the quality of research in Split, bringing new research interests and new methodology.<\/p>\n[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1766498657693{margin-bottom: 0px !important;}”]\n

Project Workflow<\/h3>\n

Second Project Year<\/h4>\n

Project Meeting III – November 4th 2025<\/h5>\n
    \n
  • I. Stojan gave a presentation on Theory of MicroScale Thermophoresis<\/li>\n
  • Attended: L. Zorani\u0107, T. Ron\u010devi\u0107, M. Male\u0161, I. Stojan and A. Budimir<\/li>\n<\/ul>\n
    Project Meeting II – July 12th 2025<\/h5>\n
      \n
    • The meeting was held as part of the work visit of our collaborators from University of Trieste, and included a team discussion focused on strategies for organizing and writing upcoming publications.<\/li>\n
    • Attended: L. Zorani\u0107, T. Ron\u010devi\u0107, A. Tossi, S. Pacor, A. Caporale, I. Stojan and A. Budimir<\/li>\n<\/ul>\n
      Project Meeting I – March 5th 2025<\/h5>\n
        \n
      • A. Begi\u0107 gave a presentation on new results of MD simulations of helminth-derived AMPs<\/li>\n
      • Attended: L. Zorani\u0107, T. Ron\u010devi\u0107, A. Tossi, S. Pacor, A. Caporale and A. Begi\u0107<\/li>\n<\/ul>\n

        First Project Year<\/h4>\n

        Project Meeting II – December 13th 2024<\/h5>\n
          \n
        • S. Pacor gave a presentation on the results of cytotoxicity assay and flow cytometry of TSO8 fragments.<\/li>\n
        • Attended: L. Zorani\u0107, T. Ron\u010devi\u0107, M. Male\u0161, A. Begi\u0107, M. Cvitkovi\u0107, A. Tossi, S. Pacor and A. Caporale<\/li>\n<\/ul>\n
          Initial Project Meeting I – March 19th 2024<\/h5>\n
            \n
          • A. Begi\u0107 gave a presentation on the results of molecular dynamics simulations of TSO8 fragments.<\/li>\n
          • Attended: L. Zorani\u0107, T. Ron\u010devi\u0107, M. Male\u0161, A. Begi\u0107, A. Tossi, S. Pacor and A. Caporale<\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"

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