{"id":9,"date":"2026-10-01T08:25:34","date_gmt":"2026-10-01T06:25:34","guid":{"rendered":"https:\/\/projects.pmfst.unist.hr\/mitoplace-home\/?page_id=9"},"modified":"2026-10-01T08:25:34","modified_gmt":"2026-10-01T06:25:34","slug":"naslovna","status":"publish","type":"page","link":"https:\/\/projects.pmfst.unist.hr\/mitoplace-home\/","title":{"rendered":"Naslovna"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row][vc_column][vc_column_text]Placenta &#8211; vrhunac morfolo\u0161kog i funkcionalnog savr\u0161enstva, uskla\u0111uje slo\u017eene biolo\u0161ke zahtjeve nu\u017ene za zdravu trudno\u0107u. Unato\u010d istra\u017eivanjima, mnogi poreme\u0107aji trudno\u0107e i dalje imaju nejasnu etiologiju. Poreme\u0107en prijenos hranjivih tvari i kisika kroz placentu u ve\u0107ini takvih poreme\u0107aja ukazuje na klju\u010dnu ulogu mitohondrija trofoblasta, metaboli\u010dke sr\u017ei posteljice, nagla\u0161avaju\u0107i da bi funkcija mitohondrija trofoblasta mogla biti klju\u010dna za razumijevanje ovih problema.Dosada\u0161nje teorije o patofiziolo\u0161kim mehanizmima placentalnih insuficijencija fokusiraju se na naru\u0161enu oksidativnu fosforilaciju i posljedi\u010dna mitohondrijska o\u0161te\u0107enja, \u0161to isti\u010de va\u017enost kontrole kvalitete mitohondrija u homeostazi placente. Ipak, karakteristike mitohondrija u placentama s preeklampsijom, naj\u010de\u0161\u0107om insuficijencijom, upu\u0107uju na postojanje alternativnog mitohondrijskog mehanizma koji regulira diferencijaciju trofoblasta, klju\u010dnog procesa razvoja placente.Projekt se fokusira na istra\u017eivanje selektivne autofagije mitohondija &#8211; mitofagije kao novog mehanizma kontrole kvalitete mitohondrija u diferencijaciji trofoblasta. Kori\u0161tenjem robusnih metodologija za transkriptomsko i proteomsko profiliranje razli\u010ditih populacija placentalnih stanica, cilj je pru\u017eiti detaljna saznanja o mehanizmima mitofagije tijekom placentogeneze zdravih i preeklampti\u010dkih placenti. Ovakvim integriranim pristupom, istra\u017eivanja na ljudskim uzorcima, mi\u0161jim modelima i trofoblastnim linijama, unaprijedit \u0107e se razumijevanje uloge mitofagije u placentogenezi i patofiziologiji placentalnih insuficijencija. Autofagija sve vi\u0161e postaje predmet intenzivnog istra\u017eivanja zbog svoje uloge u patogenezi brojnih bolesti. U tom kontekstu, krije se i mogu\u0107nost da se modifikacija autofagije koristi kao terapijska strategija. Stoga, istra\u017eivanje molekularnih mehanizama mitofagije mo\u017ee otvoriti put prema novim terapijskim pristupima za lije\u010denje placentalnih insuficijencija, za koje trenutno ne postoji u\u010dinkovita terapija.[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]Placenta &#8211; vrhunac morfolo\u0161kog i funkcionalnog savr\u0161enstva, uskla\u0111uje slo\u017eene biolo\u0161ke zahtjeve nu\u017ene za zdravu trudno\u0107u. Unato\u010d istra\u017eivanjima, mnogi poreme\u0107aji trudno\u0107e i dalje imaju nejasnu etiologiju. Poreme\u0107en prijenos hranjivih tvari i kisika kroz placentu u ve\u0107ini takvih poreme\u0107aja ukazuje na klju\u010dnu ulogu mitohondrija trofoblasta, metaboli\u010dke sr\u017ei posteljice, nagla\u0161avaju\u0107i da bi funkcija mitohondrija trofoblasta mogla biti klju\u010dna [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Naslovna - Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/projects.pmfst.unist.hr\/mitoplace-home\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Naslovna - Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text]Placenta &#8211; vrhunac morfolo\u0161kog i funkcionalnog savr\u0161enstva, uskla\u0111uje slo\u017eene biolo\u0161ke zahtjeve nu\u017ene za zdravu trudno\u0107u. Unato\u010d istra\u017eivanjima, mnogi poreme\u0107aji trudno\u0107e i dalje imaju nejasnu etiologiju. Poreme\u0107en prijenos hranjivih tvari i kisika kroz placentu u ve\u0107ini takvih poreme\u0107aja ukazuje na klju\u010dnu ulogu mitohondrija trofoblasta, metaboli\u010dke sr\u017ei posteljice, nagla\u0161avaju\u0107i da bi funkcija mitohondrija trofoblasta mogla biti klju\u010dna [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/projects.pmfst.unist.hr\/mitoplace-home\/\" \/>\n<meta property=\"og:site_name\" content=\"Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Procijenjeno vrijeme \u010ditanja\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuta\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/\",\"url\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/\",\"name\":\"Naslovna - Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/#website\"},\"datePublished\":\"2026-10-01T06:25:34+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/#breadcrumb\"},\"inLanguage\":\"hr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Po\u010detna stranica\",\"item\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Naslovna\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/#website\",\"url\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/\",\"name\":\"Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/mitoplace-home\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"hr\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Naslovna - Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/projects.pmfst.unist.hr\/mitoplace-home\/","og_locale":"hr_HR","og_type":"article","og_title":"Naslovna - Mitofagija u homeostazi placentogeneze: Uloga selektivne autofagije mitohondrija u diferencijaciji trofoblasta i placentalnim insuficijencijama","og_description":"[vc_row][vc_column][vc_column_text]Placenta &#8211; vrhunac morfolo\u0161kog i funkcionalnog savr\u0161enstva, uskla\u0111uje slo\u017eene biolo\u0161ke zahtjeve nu\u017ene za zdravu trudno\u0107u. 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