{"id":13,"date":"2021-02-18T08:23:56","date_gmt":"2021-02-18T07:23:56","guid":{"rendered":"https:\/\/projects.pmfst.unist.hr\/qacbioact\/?page_id=13"},"modified":"2021-12-14T14:41:32","modified_gmt":"2021-12-14T13:41:32","slug":"project-info","status":"publish","type":"page","link":"https:\/\/projects.pmfst.unist.hr\/qacbioact\/project-info\/","title":{"rendered":"PROJECT INFO"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1639489300913{margin-bottom: 0px !important;}&#8221;]<strong>Project title:\u00a0<\/strong>Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine<\/p>\n<p><strong>Acronym:\u00a0<\/strong>QACBioAct<\/p>\n<p><strong>Project identifier:<\/strong>\u00a0UIP-2020-02-2356<\/p>\n<p><strong>Type of project:\u00a0<\/strong>Installation Research Project<\/p>\n<p><strong>Funding body:\u00a0<\/strong>Croatian science foundation (HrZZ)<\/p>\n<p><strong>Project duration:\u00a0<\/strong>February, 01. 2021.- January, 31. 2026.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Summary<\/strong><\/p>\n<p>Quaternary ammonium compounds (QACs) are amphiphilic molecules with antimicrobial properties that have applications in numerous industries. Compounds such as benzalkonium chloride, cetylpyridinium chloride, and didecildimethylammonium chloride are commonly found in many antiseptics. Because QACs are amphiphilic molecules that act on the bacterial membrane, it has long been assumed that resistance to these compounds is virtually impossible. However, recent studies suggest that resistance to QACs is widespread not only because of Qac efflux pumps, but also because of another, as yet unknown, mechanism of resistance. Our previous studies have shown that quinuclidinium-containing derivatives can serve as a molecular scaffold for the development of new QACs. The aim of this study is to develop new derivatives of quinuclidinium-3-amide and their QACs and to investigate their biological activity. The mode of action of selected bioactive molecules is investigated by measuring membrane permeability to propidium iodide and analysing a bacterial sample with an atomic force microscope. To determine the possible influence of the compounds on the expression of Qac efflux pumps, their interaction with targeted macromolecules is studied by thermophoresis. The development of resistance and the expression of virulence factors in samples of bacterial cultures exposed to antimicrobial compounds will be analysed by mass spectrometry. The expected outcome of the proposed project is the discovery of new quinuclidinium-derived bioactive QACs that could have applications in the pharmaceutical, food and agricultural industries.[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1639489300913{margin-bottom: 0px !important;}&#8221;]Project title:\u00a0Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine Acronym:\u00a0QACBioAct Project identifier:\u00a0UIP-2020-02-2356 Type of project:\u00a0Installation Research Project Funding body:\u00a0Croatian science foundation (HrZZ) Project duration:\u00a0February, 01. 2021.- January, 31. 2026. &nbsp; Summary Quaternary ammonium compounds (QACs) are amphiphilic molecules with antimicrobial properties that have applications in numerous industries. Compounds [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-13","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PROJECT INFO - Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/projects.pmfst.unist.hr\/qacbioact\/project-info\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PROJECT INFO - Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1639489300913{margin-bottom: 0px !important;}&#8221;]Project title:\u00a0Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine Acronym:\u00a0QACBioAct Project identifier:\u00a0UIP-2020-02-2356 Type of project:\u00a0Installation Research Project Funding body:\u00a0Croatian science foundation (HrZZ) Project duration:\u00a0February, 01. 2021.- January, 31. 2026. &nbsp; Summary Quaternary ammonium compounds (QACs) are amphiphilic molecules with antimicrobial properties that have applications in numerous industries. Compounds [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/projects.pmfst.unist.hr\/qacbioact\/project-info\/\" \/>\n<meta property=\"og:site_name\" content=\"Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine\" \/>\n<meta property=\"article:modified_time\" content=\"2021-12-14T13:41:32+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/project-info\\\/\",\"url\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/project-info\\\/\",\"name\":\"PROJECT INFO - Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/#website\"},\"datePublished\":\"2021-02-18T07:23:56+00:00\",\"dateModified\":\"2021-12-14T13:41:32+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/project-info\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/project-info\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/project-info\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Po\u010detna stranica\",\"item\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PROJECT INFO\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/#website\",\"url\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/\",\"name\":\"Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine\",\"description\":\"Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/projects.pmfst.unist.hr\\\/qacbioact\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PROJECT INFO - Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/projects.pmfst.unist.hr\/qacbioact\/project-info\/","og_locale":"en_US","og_type":"article","og_title":"PROJECT INFO - Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine","og_description":"[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1639489300913{margin-bottom: 0px !important;}&#8221;]Project title:\u00a0Discovery and development of new bioactive quaternary ammonium compounds derived from quinuclidine Acronym:\u00a0QACBioAct Project identifier:\u00a0UIP-2020-02-2356 Type of project:\u00a0Installation Research Project Funding body:\u00a0Croatian science foundation (HrZZ) Project duration:\u00a0February, 01. 2021.- January, 31. 2026. &nbsp; Summary Quaternary ammonium compounds (QACs) are amphiphilic molecules with antimicrobial properties that have applications in numerous industries. 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