{"id":60,"date":"2021-06-16T12:56:18","date_gmt":"2021-06-16T10:56:18","guid":{"rendered":"https:\/\/projects.pmfst.unist.hr\/qacbioact\/?page_id=60"},"modified":"2026-09-22T12:31:16","modified_gmt":"2026-09-22T10:31:16","slug":"activities-publications","status":"publish","type":"page","link":"https:\/\/projects.pmfst.unist.hr\/qacbioact\/activities-publications\/","title":{"rendered":"ACTIVITIES, PUBLICATIONS"},"content":{"rendered":"
[vc_row][vc_column][vc_tta_tabs][vc_tta_section title=”Pokazatelji” tab_id=”1790072582626-9f82df00-330d”][mk_table]Naziv projekta: <\/strong>Otkri\u0107e i razvoj novih biolo\u0161ki aktivnih kvaternih amonijevih spojeva derivata kinuklidina<\/p>\n

Trajanje: <\/strong>1. velja\u010de 2021. \u2013 31. sije\u010dnja 2026.<\/p>\n

Voditeljica: <\/strong>izv. prof. dr. sc. Matilda \u0160prung<\/p>\n

Sa\u017eetak klju\u010dnih pokazatelja<\/h4>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Pokazatelj<\/strong><\/td>\nBroj<\/strong><\/td>\n<\/tr>\n<\/thead>\n
Znanstveni radovi u \u010dasopisima<\/td>\n9 (planirano 4 \u2014 prema\u0161eno preko dvostruko)<\/td>\n<\/tr>\n
Priop\u0107enja na skupovima<\/td>\n25<\/td>\n<\/tr>\n
\u2014 od toga pozvana predavanja<\/td>\n4<\/td>\n<\/tr>\n
\u2014 od toga posterske prezentacije<\/td>\n21<\/td>\n<\/tr>\n
Obranjene doktorske disertacije<\/td>\n2<\/td>\n<\/tr>\n
Mentorirani zavr\u0161ni radovi<\/td>\n6<\/td>\n<\/tr>\n
Mentorirani diplomski radovi<\/td>\n2<\/td>\n<\/tr>\n
Znanstvene institucije-suradnici<\/td>\n4<\/td>\n<\/tr>\n
Poha\u0111ane radionice\/\u0161kole tima<\/td>\n7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

1. Znanstveni radovi u \u010dasopisima (9)<\/h4>\n
    \n
  1. Crn\u010devi\u0107 D, Krce L, Masteli\u0107 L, Maravi\u0107 A, Soldo B, Aviani I, Primo\u017ei\u0107 I, Od\u017eak R, \u0160prung M. The mode of antibacterial action of quaternary N-benzylimidazole salts against emerging opportunistic pathogens. Bioorganic Chemistry. 2021;112:104938. doi: 10.1016\/j.bioorg.2021.104938<\/li>\n
  2. Crn\u010devi\u0107 D, Krce L, Cvitkovi\u0107 M, Brklja\u010da Z, Sablji\u0107 A, Vuko E, Primo\u017ei\u0107 I, Od\u017eak R, \u0160prung M. New Membrane Active Antibacterial and Antiviral Amphiphiles Derived from Heterocyclic Backbone of Pyridinium-4-Aldoxime. Pharmaceuticals. 2022;15:775. doi: 10.3390\/ph15070775<\/li>\n
  3. Od\u017eak R, Crn\u010devi\u0107 D, Sablji\u0107 A, Primo\u017ei\u0107 I, \u0160prung M. Synthesis and Biological Evaluation of 3-Amidoquinuclidine Quaternary Ammonium Compounds as New Soft Antibacterial Agents. Pharmaceuticals. 2023;16:187. doi: 10.3390\/ph16020187<\/li>\n
  4. Od\u017eak R, Crn\u010devi\u0107 D, Sablji\u0107 A, Krce L, Paladin A, Primo\u017ei\u0107 I, \u0160prung M. Further Study of the Polar Group’s Influence on the Antibacterial Activity of the 3-Substituted Quinuclidine Salts with Long Alkyl Chains. Antibiotics. 2023;12:1231. doi: 10.3390\/antibiotics12081231<\/li>\n
  5. Crn\u010devi\u0107 D, Rami\u0107 A, Radman Kastelic A, Od\u017eak R, Krce L, Weber I, Primo\u017ei\u0107 I, \u0160prung M. Naturally derived 3-aminoquinuclidine salts as new promising therapeutic agents. Scientific Reports. 2024;14:26211. doi: 10.1038\/s41598-024-77647-5<\/li>\n
  6. Crn\u010devi\u0107 D, Krce L, Brklja\u010da Z, Cvitkovi\u0107 M, Babi\u0107 Br\u010di\u0107 S, \u010co\u017e-Rakovac R, Od\u017eak R, \u0160prung M. A dual antibacterial action of soft quaternary ammonium compounds: bacteriostatic effects, membrane integrity, and reduced in vitro and in vivo toxicity. RSC Advances. 2025;15:1490\u20131506. doi: 10.1039\/d4ra07975b<\/li>\n
  7. Crn\u010devi\u0107 D, Od\u017eak R, \u0160prung M. A Short Review on Quaternary Ammonium Compounds (QACs): From Antibacterial Action to Next-Generation Design. Croatica Chemica Acta. 2025;98(2). doi: 10.5562\/cca4169<\/li>\n
  8. Sablji\u0107 A, \u010carija D, Rami\u0107 A, \u0160prung M, Od\u017eak R. Structure\u2013Function Insights into Quinuclidine-3-One BisQACs: Synthesis, Modulation of Bacterial Resistance, Structure\u2013Activity Relationship, and Biological Profiling. Pharmaceuticals. 2025;18:1286. doi: 10.3390\/ph18091286<\/li>\n
  9. Sablji\u0107 A, \u010carija D, Begi\u0107 K, Od\u017eak R, \u010co\u017e-Rakovac R, Toma\u0161 J, \u0160prung M. Quinuclidin-3-one-based quaternary ammonium compounds as potent antibacterials against Staphylococcus aureus and Listeria monocytogenes. Biomolecules and Biomedicine. 2026. doi: 10.17305\/bb.2026.14037<\/li>\n<\/ol>\n

    2. Pozvana predavanja (4)<\/h4>\n
      \n
    1. \u010carija, D.; Sablji\u0107, A.; Od\u017eak, R.; Krce, L.; \u0160prung, M. Quinuclidine-based quaternary ammonium compounds: A natural scaffold for antimicrobial innovation. FEBS3+ Meeting: Advances in Molecular Biosciences. Belgrade, 2025. str. 47.<\/li>\n
    2. \u0160prung, M. New generation of quaternary ammonium compounds: the potent amphiphiles in combating bacterial resistance. Solutions in Chemistry 2024. Zagreb: Hrvatsko kemijsko dru\u0161tvo, 2024. str. 26.<\/li>\n
    3. Crn\u010devi\u0107, D.; Krce, L.; Od\u017eak, R.; \u0160prung, M. Probing the membranolytic activity of novel quaternary ammonium compounds using atomic force microscopy. 2nd Croatian Microscopy Symposium. Split, 2023. str. 12\u201313.<\/li>\n
    4. Masteli\u0107, L.; Maravi\u0107, A.; Krce, L.; Soldo, B.; Od\u017eak, R.; Bu\u010devi\u0107 Popovi\u0107, V.; Aviani, I.; Primo\u017ei\u010d, I.; \u0160prung, M. New antimicrobial candidates \u2013 quaternary ammonium compounds based on natural scaffold quinuclidine. FEBS Open Bio, 11, S1 (2021), str. 101\u2013102.<\/li>\n<\/ol>\n

      3. Posterske prezentacije (21)<\/h4>\n
        \n
      1. \u010carija, D.; Od\u017eak, R.; \u0160prung, M. Quinuclidine-based soft quaternary ammonium compounds: toward safer and environmentally conscious antimicrobial agents. EFMC-ASMC 2025. Porto, 2025. str. 366.<\/li>\n
      2. Krce, L.; \u010carija, D.; \u0160prung, M. Elucidating the antibacterial mode of action of soft amidoquinuclidine-based QACs through AFM and biophysical analysis. EFMC-ASMC 2025. Porto, 2025. str. 190.<\/li>\n
      3. \u010carija, D.; Sablji\u0107, A.; Od\u017eak, R.; Krce, L.; \u0160prung, M. Quinuclidine-based quaternary ammonium compounds: A natural scaffold for antimicrobial innovation. FEBS3+ Meeting: Exploring Molecular Frontiers. Zagreb: HDBMB, 2024. str. 47.<\/li>\n
      4. Od\u017eak, R.; Sablji\u0107, A.; \u0160prung, M. Quinuclidine BisQACs: structure\u2013activity relationship analysis with focus on antimicrobial resistance. 29th Croatian Meeting of Chemists and Chemical Engineers \/ 7th Symposium Vladimir Prelog. Split, 2025. str. 165.<\/li>\n
      5. Sablji\u0107, A.; \u0160prung, M.; Od\u017eak, R. Design and synthesis of soft quaternary ammonium salts based on 3-aminoquinuclidine with amide-linked alkyl chains. 29th Croatian Meeting of Chemists and Chemical Engineers \/ 7th Symposium Vladimir Prelog. Split, 2025. str. 181.<\/li>\n
      6. Crn\u010devi\u0107, D.; Od\u017eak, R.; \u0160prung, M. Exploring enzymatic pathways for degradation of eco-friendly 3-amidoquinuclidine QACs. Solutions in Chemistry 2024. Zagreb, 2024. str. 59.<\/li>\n
      7. Crn\u010devi\u0107, D.; Krce, L.; Od\u017eak, R.; \u0160prung, M. New perspective 3-amidoquinuclidine QACs: Bacteriostatic mode of action and inhibition of protein synthesis pathways. EFMC-ISMC. Rim, 2024. str. 275.<\/li>\n
      8. Od\u017eak, R.; Crn\u010devi\u0107, D.; \u0160prung, M. New monoquaternary ammonium surfactants and their permeability through modeled biomembrane. Solutions in Chemistry 2024. Zagreb, 2024. str. 89.<\/li>\n
      9. Crn\u010devi\u0107, D.; Primo\u017ei\u010d, I.; Krce, L.; \u0160prung, M.; Od\u017eak, R. 3-aminoquinuclidine quaternary salts – new generation of potent antibacterial agents. EFMC-ISMC. 2024. str. 359.<\/li>\n
      10. Od\u017eak, R.; Sablji\u0107, A.; \u0160prung, M. Quaternary 3-Quinuclidinone Compounds: Potent Antibacterial Agents Against Staphylococcus aureus and Listeria monocytogenes. 27th Congress of SCTM. Skoplje, 2024. str. 141.<\/li>\n
      11. Sablji\u0107, A.; \u0160prung, M.; Od\u017eak, R. Natural Derived Mono- and bisQACs from Quinuclidine Backbone as an Alternative to Commercial Disinfectants. 2nd Workshop on Mass Spectrometry in Life Sciences. Zagreb, 2024. str. 42.<\/li>\n
      12. Sablji\u0107, A.; Crn\u010devi\u0107, D.; \u0160prung, M.; Od\u017eak, R. The influence of amide group addition on the bioactivity of new soft 3-amidoquinuclidine QACs. 28th Croatian Meeting of Chemists and Chemical Engineers. Zagreb, 2023. str. 122.<\/li>\n
      13. \u0160prung, M.; Crn\u010devi\u0107, D.; Sablji\u0107, A.; Od\u017eak, R. New insights into quaternary ammonium compounds: from structure-activity optimization to antibacterial mode of action. IX EFMC-ASMC. Louvain-la-Neuve, 2023. str. 313.<\/li>\n
      14. Crn\u010devi\u0107, D.; Sablji\u0107, A.; Od\u017eak, R.; \u0160prung, M. Biological activity of novel environmentally compatible 3-amidoquinuclidine quaternary ammonium compounds. IX EFMC-ASMC. Louvain-la-Neuve, 2023. str. 140.<\/li>\n
      15. Sablji\u0107, A.; Crn\u010devi\u0107, D.; \u0160prung, M.; Od\u017eak, R. Biological evaluation of 3-aminoquinuclidine QACs with long alkyl chains as new potent antimicrobial agents. IX EFMC-ASMC. Louvain-la-Neuve, 2023. str. 298.<\/li>\n
      16. Crn\u010devi\u0107, D.; Sablji\u0107, A.; Krce, L.; Primo\u017ei\u010d, I.; Od\u017eak, R.; \u0160prung, M. Amidoquinuclidine salts with potent activity against Listeria monocytogenes. EFMC-ISMC 2022. Nica, 2022. str. 219.<\/li>\n
      17. Sablji\u0107, A.; Crn\u010devi\u0107, D.; \u0160prung, M.; Od\u017eak, R. Synthesis and antibacterial activity of 3-aminoquinuclidine quaternary ammonium salts. 6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry. Zagreb, 2022. str. 5.<\/li>\n
      18. Crn\u010devi\u0107, D.; Krce, L.; Cvitkovi\u0107, M.; Sablji\u0107, A.; Primo\u017ei\u010d, I.; Od\u017eak, R.; \u0160prung, M. New membrane active antimicrobial amphiphiles derived from heterocyclic backbone of pyridinium-4-aldoxime. EFMC-ISMC 2022. Nica, 2022. str. 220.<\/li>\n
      19. Biland\u017ei\u0107, K.; Od\u017eak, R.; \u0160prung, M. Biological activity of 3-aminoquinuclidine quaternary salt. Zagreb: HKD, 2022. str. 85.<\/li>\n
      20. Crn\u010devi\u0107, D.; Od\u017eak, R.; \u0160prung, M. Amido-quinuclidine based QACs as a new soft antimicrobial agents susceptible to protease degradation. 2021. str. 420.<\/li>\n
      21. Crn\u010devi\u0107, D.; Sablji\u0107, A.; Od\u017eak, R.; \u0160prung, M. Synthesis and antibacterial activities of new amidoquinuclidines and their quaternary salts. 2021. str. 11.<\/li>\n<\/ol>\n

        4. Doktorske disertacije proiza\u0161le iz projekta (2)<\/h4>\n
          \n
        1. Doris \u010carija (Crn\u010devi\u0107) \u2014 Struktura, biolo\u0161ka aktivnost i mehanizam djelovanja novosintetiziranih kvaternih amonijevih spojeva (obranjena 14. o\u017eujka 2025.)<\/li>\n
        2. Antonio Sablji\u0107 \u2014 Sinteza i biolo\u0161ka aktivnost mono- i biskvaternih amonijevih spojeva na okosnici 1-azabiciklo[2.2.2]oktana (obranjena 8. prosinca 2025.)<\/li>\n<\/ol>\n

          5. Mentorirani ocjenski radovi studenata (8)<\/h4>\n

          Sveu\u010dili\u0161ni zavr\u0161ni radovi (6)<\/h4>\n
            \n
          1. Naki\u0107 Terzi\u0107, Lara Marie \u2014 Toksi\u010dnost kvaternih amonijevih spojeva, PMF Split, 2026.<\/li>\n
          2. Selak, Branimir \u2014 Mehanizmi bakterijske rezistencije prema kvaternim amonijevim spojevima, PMF Split, 2025.<\/li>\n
          3. Mo\u010di\u0107, Matea \u2014 Antimikrobna aktivnost kvaternih fosfonijevih spojeva, PMF Split, 2024.<\/li>\n
          4. \u017dili\u0107, \u017dana \u2014 Biolo\u0161ka aktivnost kvaternih amonijevih spojeva, PMF Split, 2024.<\/li>\n
          5. Biland\u017ei\u0107, Katijana \u2014 Biolo\u0161ka aktivnost kvarterne soli 3-aminokinuklidina, Split, 2022.<\/li>\n
          6. \u0106uri\u0107, Lucijana \u2014 Komercijalne kvaterne amonijeve soli \u2013 potencijalni supstrati Qac efluks pumpi, PMF Split, 2022.<\/li>\n<\/ol>\n

            Sveu\u010dili\u0161ni diplomski radovi (2)<\/h4>\n
              \n
            1. Vitovski, Mihaela \u2014 Oligomerizacijsko stanje transkripcijskog regulatora QacR iz bakterije Staphylococcus aureus, PMF Split, 2023.<\/li>\n
            2. Vidakovi\u0107, Josip \u2014 Heterologna ekspresija i pro\u010di\u0161\u0107avanje transkripcijskog faktora QacR iz bakterije Escherichia coli, PMF Split, 2021.<\/li>\n<\/ol>\n

              6. Znanstvene suradnje<\/h4>\n
                \n
              1. PMF Sveu\u010dili\u0161ta u Zagrebu \u2013 Kemijski odsjek (dr. sc. Ines Primo\u017ei\u0107, dr. sc. Alma Rami\u0107, dr. sc. Andreja Radman Kastelic) \u2014 dizajn, sinteza i NMR\/strukturna karakterizacija kinuklidinskih derivata<\/li>\n
              2. Institut Ru\u0111er Bo\u0161kovi\u0107, Zagreb (dr. sc. Rozelindra \u010co\u017e-Rakovac, dr. sc. Sanja Babi\u0107 Br\u010di\u0107, dr. sc. Karolina Begi\u0107) \u2014 biotehnologija u akvakulturi, kemija materijala<\/li>\n
              3. Selvita Ltd., Zagreb (dr. sc. Zlatko Brklja\u010da) \u2014 ra\u010dunalne simulacije i molekularna dinamika<\/li>\n
              4. Odjel za fiziku, PMF Split (dr. sc. Lucija Krce, dr. sc. Mislav Cvitkovi\u0107) \u2014 AFM, SEM, fluorescencijske i ra\u010dunalne analize<\/li>\n<\/ol>\n

                7. Usavr\u0161avanja \u010dlanova projektnog tima<\/h4>\n
                  \n
                1. Introduction to mass spectrometry in biomedical research \u2014 PMF, Split, 2023.<\/li>\n
                2. LC\/MS analysis of proteins \u2014 BIOcentar, Zagreb, 2023.<\/li>\n
                3. Monolith User Training \u2014 NanoTemper Technologies GmbH, M\u00fcnchen, 2023.<\/li>\n
                4. Flow Cytometry Education: From first principles to polychromatic applications \u2014 MEFST, Split, 2022.<\/li>\n
                5. MedILS Summer School in Bioinformatics \u2014 Mediteranski institut za istra\u017eivanje \u017eivota, Split, 2022.<\/li>\n
                6. MedILS Summer School in Science Communication \u2014 Mediteranski institut za istra\u017eivanje \u017eivota, Split, 2022.<\/li>\n
                7. European School of Medicinal Chemistry \u2014 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD students \u2014 Urbino, Italija, 2022.<\/li>\n<\/ol>\n[\/mk_table][\/vc_tta_section][vc_tta_section title=”ACTIVITIES” tab_id=”1790072794046-80f2dc09-7172″][vc_column_text css=”.vc_custom_1708431284322{margin-bottom: 0px !important;}”]ACTIVITES<\/strong><\/p>\n

                  1.) LECTURES<\/strong><\/p>\n