MitoPlace_HOME focuses on the role of mitochondrial quality control in trophoblast differentiation and placental insufficiency. The project connects changes in mitochondrial structure and function with mitophagy, trophoblast differentiation and pregnancy complications.
Trophoblast differentiation
Understanding how trophoblast cells differentiate and how mitochondrial structure and function change during this process.
Mitophagy & mitochondrial dynamics
Investigating how selective mitochondrial removal, together with mitochondrial fission and fusion, contributes to mitochondrial adaptation and quality control in placental cells.
Placental insufficiency
Exploring whether alterations in mitochondrial quality control contribute to placental dysfunction, with particular focus on preeclampsia and preterm birth.
